Axon and target communicate to organize synaptic differentiation.

synapse organizers

Key Presynaptic organizers: NT-7a, neuroligin, synaptic cell adhesion molecule (SynCAM) and fibroblast growth factor-22 (FGF-22) have all been identified as target-derived presynaptic organizers Key Postsynaptic organizers: axon-derived neuronal activity regulated pentraxin (Narp), ephrinB and neurexin reciprocally co-ordinate postsynaptic differentiation. Seeking long-term relationship: axon and target communicate to organize synaptic differentiation. J Neurochem. 2006 Jun;97(5):1215-31. Epub … Continue reading

Stunning Details of Brain Connections: Single-Synapse Analysis of a Diverse Synapse Population: Proteomic Imaging Methods and Markers @ STANFORD

Journal Reference: Kristina D. Micheva, Brad Busse, Nicholas C. Weiler, Nancy O’Rourke, Stephen J Smith. Single-Synapse Analysis of a Diverse Synapse Population: Proteomic Imaging Methods and Markers. Neuron, Volume 68, Issue 4, 639-653, 18 November 2010 DOI: 10.1016/j.neuron.2010.09.024 ScienceDaily (Nov. 17, 2010) — Researchers at the Stanford University School of Medicine, applying a state-of-the-art imaging … Continue reading

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