Rewiring of the Visual Cortex in the Congenitally Blind: Evidence for experience-dependant plasticity @ UDM

http://www.pnas.org/content/early/2011/02/23/1013928108.abstract Functional specialization for auditory–spatial processing in the occipital cortex of congenitally blind humans 1. Olivier Collignona,b,1,2. Gilles Vandewallec,3. Patrice Vossa,4. Geneviève Albouyc,5. Geneviève Charbonneaua,6. Maryse Lassondea,b, and7. Franco Leporea. #aCentre de Recherche en Neuropsychologie et Cognition, Université de Montréal, Montreal, QC, Canada H3C 3J7;#bCentre de Recherches, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada H3T … Continue reading

Reversing pathological neural activity using targeted plasticity

Navzer D. Engineer, Jonathan R. Riley, Jonathan D. Seale, Will A. Vrana, Jai A. Shetake, Sindhu P. Sudanagunta, Michael S. Borland & Michael P. Kilgard AffiliationsContributionsCorresponding author Nature (2011) doi:10.1038/nature09656 Received 14 June 2010 Accepted 08 November 2010 Published online 12 January 2011 Abstract Brain changes in response to nerve damage or cochlear trauma can … Continue reading

Molecular Basis of Plasticity: SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning

Neurons that fire together wire together. Adhesion molecule SynCAM1: promotes new synapses in the developing brain, holds synaptic junctions together, and impacts the maintenance and function of these structure. Elissa M. Robbins, Alexander J. Krupp, Karen Perez de Arce, Ananda K. Ghosh, Adam I. Fogel, Antony Boucard, Thomas C. Südhof, Valentin Stein, Thomas Biederer Summary … Continue reading

Axon and target communicate to organize synaptic differentiation.

Key Presynaptic organizers: NT-7a, neuroligin, synaptic cell adhesion molecule (SynCAM) and fibroblast growth factor-22 (FGF-22) have all been identified as target-derived presynaptic organizers Key Postsynaptic organizers: axon-derived neuronal activity regulated pentraxin (Narp), ephrinB and neurexin reciprocally co-ordinate postsynaptic differentiation. Seeking long-term relationship: axon and target communicate to organize synaptic differentiation. J Neurochem. 2006 Jun;97(5):1215-31. Epub … Continue reading

TED TALK: Michael Merzenich on re-wiring the brain

Ted Talk April 2009 Michael Merzenich on re-wiring the brain The brain is constructed for change. It confers on us the ability to do things to tomorrow that we can’t do today, things today that we couldn’t do yesterday. Infancy: The brain is born stupid. At birth, there is no indication that there is any … Continue reading

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