Deep Brain Stimulation: Adenosine is crucial for DBS–mediated attenuation of tremor

Deep brain stimulation is a surgical treatment where electrodes, or brain pacemakers, are implanted into specific areas of the brain to drive an electrical jolt. The mechanism by which DBS results in the treatment of Parkinsons, Dystonia, Tremor, Chronic pain is still not clearly understood. DBS has been also used to treat tourettes, OCD, phantom … Continue reading

Neurobiochemical Foundations of Sleep: ATP and the purine type 2 X7 receptor affect sleep

Abstract Sleep is dependent upon prior brain activities, e.g., after prolonged wakefulness sleep rebound occurs. These effects are mediated, in part, by humoral sleep regulatory substances such as cytokines. However, the property of wakefulness activity that initiates production and release of such substances and thereby provides a signal for indexing prior waking activity is unknown. … Continue reading

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