Cognition enhancement strategies

Cognition enhancement strategies. J Neurosci. 2010 Nov 10;30(45):14987-92. Bibb JA, Mayford MR, Tsien JZ, Alberini CM. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. james.bibb@utsouthwestern.edu Abstract Many mental disorders and neurodegenerative and neurodevelopmental diseases involve cognitive deficits. Remarkable advances and new technologies are providing a clearer picture of the molecular … Continue reading

Reversing pathological neural activity using targeted plasticity

Navzer D. Engineer, Jonathan R. Riley, Jonathan D. Seale, Will A. Vrana, Jai A. Shetake, Sindhu P. Sudanagunta, Michael S. Borland & Michael P. Kilgard AffiliationsContributionsCorresponding author Nature (2011) doi:10.1038/nature09656 Received 14 June 2010 Accepted 08 November 2010 Published online 12 January 2011 Abstract Brain changes in response to nerve damage or cochlear trauma can … Continue reading

A Wireless Brain-Machine Interface for Real-Time Speech Synthesis

Figure 1. Schematic of the brain-machine interface for real-time synthetic speech production. Black circles and curved arrows represent neurons and axonal projections, respectively, in the neural circuitry for speech motor output. The volunteer’s stroke-induced lesion in the efferent motor pathways (red X) disconnects motor plans represented in the cerebral cortex from the speech motoneurons, thus disabling speech output while sparing somatic, auditory, and visual sensation as well as speech motor planning centers in cerebral cortex. Signals collected from an electrode implanted in the subject’s speech motor cortex are amplified and sent wirelessly across the scalp as FM radio signals. The signals are then routed to an electrophysiology recording system for further amplification, analog-to-digital conversion, and spike sorting. The sorted spikes are sent to a Neural Decoder which translates them into commands for a Speech Synthesizer. Audio signals from the synthesizer are fed back to the subject in real time. [Abbreviation: PrCG = precentral gyrus.] doi:10.1371/journal.pone.0008218.g001

A Wireless Brain-Machine Interface for Real-Time Speech Synthesis Frank H. Guenther1,2*, Jonathan S. Brumberg1,3, E. Joseph Wright3, Alfonso Nieto-Castanon4, Jason A. Tourville1, Mikhail Panko1, Robert Law1, Steven A. Siebert3, Jess L. Bartels3, Dinal S. Andreasen3,5, Princewill Ehirim6, Hui Mao7, Philip R. Kennedy3 1 Department of Cognitive and Neural Systems and Sargent College of Health and … Continue reading

TED TALK: Michael Merzenich on re-wiring the brain

Ted Talk April 2009 Michael Merzenich on re-wiring the brain The brain is constructed for change. It confers on us the ability to do things to tomorrow that we can’t do today, things today that we couldn’t do yesterday. Infancy: The brain is born stupid. At birth, there is no indication that there is any … Continue reading

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