Cortical Neural Prostheses turns memory on an off


A cortical neural prosthesis for restoring and enhancing memory Theodore W Berger1, Robert E Hampson2, Dong Song1, Anushka Goonawardena2, Vasilis Z Marmarelis1 and Sam A Deadwyler2 1 Depatment of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA 2 Department of Physiology and Pharmacology, Wake Forest University, Winston-Salem, NC, USA ABSTRACT A primary objective … Continue reading

Novel Brain-Machine-Interface allows you to Control and Steer a car


Scientists Steer Car With the Power of Thought Freie Universitaet Berlin (2011, February 21). Scientists steer car with the power of thought. ScienceDaily. Retrieved February 21, 2011, from­ /releases/2011/02/110218083711.htm Excerpt “The scientists from Freie Universität first used the sensors for measuring brain waves in such a way that a person can move a virtual … Continue reading

New two-photon calcium microscope records Firing of Thousands of Individual Neurons in 3-D

calcium imaging

UCLA neuroscientists have collaborated with physicists to develop a non-invasive, ultra-high-speed microscope that can record in real time the firing of thousands of individual neurons in the brain as they communicate, or miscommunicate, with each other. Simultaneous two-photon calcium imaging at different depths with spatiotemporal multiplexing Adrian Cheng, J Tiago Gonçalves, Peyman Golshani, Katsushi Arisaka … Continue reading

Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient


Remission of Major Depression Under Deep Brain Stimulation of the Lateral Habenula in a Therapy-Refractory Patient Alexander Sartorius a, , Karl L. Kiening b, Peter Kirsch c, Carl C. von Gall d, Uwe Haberkorn d, Andreas W. Unterberg e, Fritz A. Henn f and Andreas Meyer-Lindenberg g a Department of Psychiatry and Psychotherapy, Central Institute … Continue reading

Neurogenic hippocampal targets of deep brain stimulation.

Neurogenic hippocampal targets of deep brain stimulation. J Comp Neurol. 2011 Jan 1;519(1):6-20. Encinas JM, Hamani C, Lozano AM, Enikolopov G. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA. Deep brain stimulation (DBS) is being used to treat movement, neurological, and psychiatric disorders; recently it has been successfully applied to patients with … Continue reading

A Wireless Brain-Machine Interface for Real-Time Speech Synthesis

Figure 1. Schematic of the brain-machine interface for real-time synthetic speech production. Black circles and curved arrows represent neurons and axonal projections, respectively, in the neural circuitry for speech motor output. The volunteer’s stroke-induced lesion in the efferent motor pathways (red X) disconnects motor plans represented in the cerebral cortex from the speech motoneurons, thus disabling speech output while sparing somatic, auditory, and visual sensation as well as speech motor planning centers in cerebral cortex. Signals collected from an electrode implanted in the subject’s speech motor cortex are amplified and sent wirelessly across the scalp as FM radio signals. The signals are then routed to an electrophysiology recording system for further amplification, analog-to-digital conversion, and spike sorting. The sorted spikes are sent to a Neural Decoder which translates them into commands for a Speech Synthesizer. Audio signals from the synthesizer are fed back to the subject in real time. [Abbreviation: PrCG = precentral gyrus.] doi:10.1371/journal.pone.0008218.g001

A Wireless Brain-Machine Interface for Real-Time Speech Synthesis Frank H. Guenther1,2*, Jonathan S. Brumberg1,3, E. Joseph Wright3, Alfonso Nieto-Castanon4, Jason A. Tourville1, Mikhail Panko1, Robert Law1, Steven A. Siebert3, Jess L. Bartels3, Dinal S. Andreasen3,5, Princewill Ehirim6, Hui Mao7, Philip R. Kennedy3 1 Department of Cognitive and Neural Systems and Sargent College of Health and … Continue reading

MRI-Visible Micellar Nanomedicine for Targeted Drug Delivery to Lung Cancer Cells


Polymeric micelles are emerging as a highly integrated nanoplatform for cancer targeting, drug delivery and tumor imaging applications. In this study, we describe a multifunctional micelle (MFM) system that is encoded with a lung cancer-targeting peptide (LCP), and encapsulated with superparamagnetic iron oxide (SPIO) and doxorubicin (Doxo) for MR imaging and therapeutic delivery, respectively. The … Continue reading

Reading and controlling human brain activation using real-time functional magnetic resonance imaging (rt-fMRI)

rt frmi

Reading and controlling human brain activation using real-time functional magnetic resonance imaging R. Christopher deCharms Omneuron 3T MRI Research Center, Menlo Park, CA 94025, USA TRENDS in Cognitive Sciences Vol.11 No.11 ABSTRACT Understanding how to control how the brain’s functioning mediates mental experience and the brain’s processing to alter cognition or disease are central projects … Continue reading

List of Neuroimaging Software


Neuroimaging software is used to study the structure and function of the brain. The ultimate source of neuroimaging tools and software: NITRC This website contains the NIH Blueprint for Neuroscience Research funded clearinghouse of many of software applications, as well as hardware. 1. 3D Slicer developed at Harvard has many uses, including diffusion tensor imaging … Continue reading

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