Milestone: The X-ray Crystal structure of the voltage gated sodium channel

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The crystal structure of a voltage-gated sodium channel Jian Payandeh, Todd Scheuer, Ning Zheng & William A. Catterall Department of Pharmacology, University of Washington, Seattle, Washington 98195, USA Jian Payandeh, Todd Scheuer, Ning Zheng & William A. Catterall Howard Hughes Medical Institute, University of Washington, Seattle, Washington 98195, USA Ning Zheng Voltage-gated sodium (NaV) channels … Continue reading

Combining Crystallography and Physical Chemistry (FRET) to study the conformations of fast excitatory AMPA receptors


FRET = single-molecule fluorescence resonance energy transfer Structural landscape of isolated agonist-binding domains from single AMPA receptors NATURE CHEMICAL BIOLOGY | ARTICLE Christy F Landes, Anu Rambhadran, J Nick Taylor, Ferandre Salatan & Vasanthi Jayaraman AffiliationsContributionsCorresponding authors Nature Chemical Biology (2011) doi:10.1038/nchembio.523 Received 15 June 2010 Accepted 06 January 2011 Published online 06 February 2011 … Continue reading

Cognition enhancement strategies

Cognition enhancement strategies. J Neurosci. 2010 Nov 10;30(45):14987-92. Bibb JA, Mayford MR, Tsien JZ, Alberini CM. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA. Abstract Many mental disorders and neurodegenerative and neurodevelopmental diseases involve cognitive deficits. Remarkable advances and new technologies are providing a clearer picture of the molecular … Continue reading

α-Synuclein protein advances Parkinson’s by preventing neurons from clearing debris


α-Synuclein impairs macroautophagy: implications for Parkinson’s disease JCB Home > 2010 Archive > 20 September > Winslow et al. 190 (6): 1023 Ashley R. Winslow1, Chien-Wen Chen1,3, Silvia Corrochano4, Abraham Acevedo-Arozena4, David E. Gordon2, Andrew A. Peden2, Maike Lichtenberg1, Fiona M. Menzies1, Brinda Ravikumar1, Sara Imarisio1,3, Steve Brown4, Cahir J. O’Kane3, and David C. Rubinsztein1 … Continue reading

Molecular Basis of Plasticity: SynCAM 1 Adhesion Dynamically Regulates Synapse Number and Impacts Plasticity and Learning


Neurons that fire together wire together. Adhesion molecule SynCAM1: promotes new synapses in the developing brain, holds synaptic junctions together, and impacts the maintenance and function of these structure. Elissa M. Robbins, Alexander J. Krupp, Karen Perez de Arce, Ananda K. Ghosh, Adam I. Fogel, Antony Boucard, Thomas C. Südhof, Valentin Stein, Thomas Biederer Summary … Continue reading

Axon and target communicate to organize synaptic differentiation.

synapse organizers

Key Presynaptic organizers: NT-7a, neuroligin, synaptic cell adhesion molecule (SynCAM) and fibroblast growth factor-22 (FGF-22) have all been identified as target-derived presynaptic organizers Key Postsynaptic organizers: axon-derived neuronal activity regulated pentraxin (Narp), ephrinB and neurexin reciprocally co-ordinate postsynaptic differentiation. Seeking long-term relationship: axon and target communicate to organize synaptic differentiation. J Neurochem. 2006 Jun;97(5):1215-31. Epub … Continue reading

Neurogenesis in the adult human hippocampus


Neurogenesis in the adult human hippocampus Nature Medicine 4, 1313 – 1317 (1998) doi:10.1038/3305 Peter S. Eriksson1, 4, Ekaterina Perfilieva1, Thomas Björk-Eriksson2, Ann-Marie Alborn1, Claes Nordborg3, Daniel A. Peterson4 & Fred H. Gage4 1 Department of Clinical Neuroscience, Institute of Neurology, Sahlgrenska University Hospital, 41345 Göteborg , Sweden 2 Department of Clinical Neuroscience, Department of … Continue reading

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

Photomicrographs of BrdU-positive cells

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus Nature Neuroscience 2, 266 – 270 (1999) doi:10.1038/6368 Henriette van Praag1, Gerd Kempermann1, 2 & Fred H. Gage1 1 Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037, USA 2 Department of Neurology, University … Continue reading

Pain: Sites of Origin, Pathways, and Neurotransmitters

Pain: Sites of Origin, Pathways, and Neurotransmitters Source: Canadian Council on Animal Care The precise mechanisms of pain appreciation in the central nervous system have not been fully elucidated although much is known of the pathways involved. Some of the transmitters and receptors that play an important role in pain have been identified. This has … Continue reading

Investigating the neurobiology of music: BDNF modulation in the hippocampus of young adult mice.

Investigating the neurobiology of music: brain-derived neurotrophic factor modulation in the hippocampus of young adult mice. Behav Pharmacol. 2007 Sep;18(5-6):491-6. Angelucci F, Fiore M, Ricci E, Padua L, Sabino A, Tonali PA. Fondazione Don C. Gnocchi, Catholic University, Largo Gemelli, Rome, Italy. Abstract It has been shown that music might be able to improve … Continue reading

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