Neurogenesis in the adult human hippocampus

Neurogenesis in the adult human hippocampus


Nature Medicine 4, 1313 – 1317 (1998)
doi:10.1038/3305
Peter S. Eriksson1, 4, Ekaterina Perfilieva1, Thomas Björk-Eriksson2, Ann-Marie Alborn1, Claes Nordborg3, Daniel A. Peterson4 & Fred H. Gage4

1 Department of Clinical Neuroscience, Institute of Neurology, Sahlgrenska University Hospital, 41345 Göteborg , Sweden
2 Department of Clinical Neuroscience, Department of Oncology, Sahlgrenska University Hospital, 41345 Göteborg , Sweden
3 Department of Clinical Neuroscience, Department of Pathology, Sahlgrenska University Hospital, 41345 Göteborg , Sweden
4 Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla , California 92037, USA

Abstract
The genesis of new cells, including neurons, in the adult human brain has not yet been demonstrated. This study was undertaken to investigate whether neurogenesis occurs in the adult human brain, in regions previously identified as neurogenic in adult rodents and monkeys. Human brain tissue was obtained postmortem from patients who had been treated with the thymidine analog, bromodeoxyuridine (BrdU), that labels DNA during the S phase. Using immunofluorescent labeling for BrdU and for one of the neuronal markers, NeuN, calbindin or neuron specific enolase (NSE), we demonstrate that new neurons, as defined by these markers, are generated from dividing progenitor cells in the dentate gyrus of adult humans. Our results further indicate that the human hippocampus retains its ability to generate neurons throughout life.

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